Importance of geometry of the extracellular matrix in endochondral bone differentiation.

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Importance of geometry of the extracellular matrix in endochondral bone differentiation

Subcutaneous implantation of coarse powders (74-420 micron) of demineralized diaphyseal bone matrix resulted in the local differentiation of endochondral bone. However, implantation of matrix with particle size of 44-74 micron (Fine matrix) did not induce bone. We have recently reported that the dissociative extraction of coarse matrix with 4 M guanidine HCl resulted in a complete loss of the a...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1984

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.98.6.2192